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Drug Biotransformation & Molecular Mechanisms of Toxicity

  • PHA 6425 Drug Biotransformation & Molecular Mechanisms of Toxicity

    Description

    This course provides a strong conceptual foundation of enzymology and mechanisms of drug biotransformation pathways. As a foundation for learning, we will provide examples of drugs and other xenobiotics that exhibit toxicity related to biotransformation. Students are expected to use information presented in each module to develop and complete given assignments. Other activities will include online discussions of current news articles and scientific publications that relate to drug metabolism, toxicology and biochemistry.

    Prerequisites

    Please review our recommended course order.

    Topics

    Module Topic
    Module 1 Overview of Xenobiotic Metabolism
    Module 2 Cytochrome P450
    Module 3 Flavin Monooxygenase and Other Oxidative Enzymes
    Module 4 Ester/Amide Hydrolysis
    Module 5 Epoxide Hydrolases
    Module 6 Glucuronosyltransferases and Glucosyltransferase
    Module 7 Sulfotransferases
    Module 8 Glutathione S-transferases
    Module 9 Other Phase II Reactions
    Module 10 Transport of Xenobiotics and Their Metabolites
    Module 11 Metabolism and Toxicity General Concepts
    Module 12 Metabolic Activation of Drugs
    Module 13 Metabolic Activation of Industrial Chemicals
    Module 14 Metabolic Activation of Pyrolysis Products
    Module 15 Metabolic Activation of Natural Products

    Materials

    Required Materials

    There is no single recommended text for this course. Helpful textbooks include:

    • Introduction to Drug Metabolism
      Author: G. Gordon Gibson and Paul Skett
      Publisher: Nelson Thornes Company; 3rd edition (9/1/2001)
      ISBN: 0748760113
    • Enzyme systems that metabolise drugs and other xenobiotics
      Author: Ioannides & Costa (editors)
      Publisher: Wiley, 1st edition (12/31/2001)
      ASIN: B008F1DOUY
    • Cytochrome P450: Structure, Mechanism, and Biochemistry
      Author: Paul R. Ortiz De Montellano
      Publisher: Kluwer Academic Publishers; 3rd edition (12/21/2004)
      ISBN: 0306483246

    Library Access

    Distance Education and UF Online Students enjoy the same library privileges as on-campus students.
    To utilize the University of Florida Library System, click here!


    Tuition: $1,725

    At a Glance