This is a 3-credit course.
This course provides a strong conceptual foundation of enzymology and mechanisms of drug biotransformation pathways. As a foundation for learning, we will provide examples of drugs and other xenobiotics that exhibit toxicity related to biotransformation. Students are expected to use information presented in each module to develop and complete given assignments. Other activities will include online discussions of current news articles and scientific publications that relate to drug metabolism, toxicology and biochemistry.
|Overview of Xenobiotic Metabolism
|Flavin Monooxygenase and Other Oxidative Enzymes
|Glucuronosyltransferases and Glucosyltransferase
|Other Phase II Reactions
|Transport of Xenobiotics and Their Metabolites
|Metabolism and Toxicity General Concepts
|Metabolic Activation of Drugs
|Metabolic Activation of Industrial Chemicals
|Metabolic Activation of Pyrolysis Products
|Metabolic Activation of Natural Products
There is no single recommended text for this course. Helpful textbooks include:
- Introduction to Drug Metabolism
Author: G. Gordon Gibson and Paul Skett
Publisher: Nelson Thornes Company; 3rd edition (9/1/2001)
- Enzyme systems that metabolise drugs and other xenobiotics
Author: Ioannides & Costa (editors)
Publisher: Wiley, 1st edition (12/31/2001)
- Cytochrome P450: Structure, Mechanism, and Biochemistry
Author: Paul R. Ortiz De Montellano
Publisher: Kluwer Academic Publishers; 3rd edition (12/21/2004)
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